What do vault particles do? Scientists have been asking this for 40 years. Our biology team at Anthropic set out to tackle this long-standing open question in cell biology, working with Claude.
We haven't uncovered their biological function yet, but we've found something new: vault proteins in prokaryotes that assemble into complexes that are larger than human vaults. And we show that we can engineer their shapes to produce even larger nanocapsules!
The mystery of vaults goes deeper than anyone knew...
Read the blog and technical report to learn more!
Blog: t.co/cLy5gq7aFN
Technical report: t.co/t3KXpKKB4s
Very grateful to have such fantastic coauthors who made this research project possible, including Januka Athukoralage, @ntperry13, @PeterHYoon, @ekabrams, and @amirshanehsaz. A big thank you to Dr. Leonard Rome, who discovered vaults in 1986, for providing feedback on the technical report. Thank you to @FutureHouseSF for supporting me as a research fellow when I first started learning about vaults. And, of course, grateful to my many @AnthropicAI teammates that work tirelessly to make Claude the best model for biology!
Video and sound made by Claude (with artistic direction from @ntperry13). Showing the new bacteriophage-derived vault structure that we solved.
Science
Prokaryotic vault complexes larger than human vaults found with Claude
Anthropic researchers discovered prokaryotic vault proteins that assemble into complexes larger than human vaults, and engineered shapes to create even larger nanocapsules, working with Claude.
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